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Design
Review
Synthesizes SERCA2 isoform knowledge; leaves open isoform-specific therapeutic exploration in heart failure.
Ca(2+)-uptake into intracellular stores is mediated by the sarco/endoplasmic reticulum Ca(2+)ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA2 transcript processing. Secondly, the two different protein isoforms and their regulation are described. Finally, this review ends with a discussion on the possible physiological role of the SERCA2 isoform diversity.
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Verboomen et al. (1995) studied this question.
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