Key result
SERCA and PMCA Ca2+ pump gene transcripts undergo alternative processing in a differentiation- and tissue-dependent manner, generating isoforms with distinct functional properties.
This review highlights the diversity and functional implications of alternative processing in SERCA and PMCA Ca2+ pump isoforms in muscle and brain.
Isoform diversity in SERCA/PMCA warrants caution interpreting Ca2+ handling; leaves open tissue-specific functional validation.
Eukaryotic cells express one or more isoforms of a sarco(endo)plasmic reticulum (SERCA) and of a plasma membrane (PMCA) Ca2+ pump. Both the SERCA and PMCA gene transcripts are subject to alternative processing in a differentiation stage-dependent and tissue-dependent manner. The Ca2+ pump isoforms thus generated may present different functional properties. This is exemplified by the SERCA2a and SERCA2b isoforms which differ in their Ca2+ sensitivity. Analysis of the cDNA structures for PMCA1 predicts protein isoforms with variant calmodulin- and phospholipid-binding domains. A comparative study of the tissue-specific mechanisms governing SERCA-PMCA transcript processing and a more detailed study of the functional implication of the PMCA pumps isoform diversity will be challenging subjects for future studies.
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Wuytack et al. (1992) reported a review. SERCA and PMCA Ca2+ pump gene transcripts undergo alternative processing in a differentiation- and tissue-dependent manner, generating isoforms with distinct functional properties.
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