Le blocage de la lysine par la réaction de M AILLARD . I. Synthèse de N‐(désoxy‐1‐ D ‐fructosyl‐1)‐ et N‐(désoxy‐1‐ D ‐lactulosyl‐1)‐ L ‐lysines

The authors describe a specific method for the preparation of Nϵ‐(1‐deoxy‐D‐fructosyl)‐L‐lysine, Nα‐(1‐deoxy‐D‐fructosyl)‐L‐lysine, their formyl derivatives, and Nα‐formyl‐ϵ‐(1‐deoxy‐D‐lactulosyl)‐L‐lysine, as well as Nα, Nϵ‐di‐(1‐deoxy‐D‐fructosyl)‐L‐lysine. After purification by cation‐exchange chromatography using volatile pyridine‐acetic acid or pyridine‐formic acid buffers, these compounds are obtained in the pure state. By thin‐layer chromatography and paper electrophoresis these lysine derivatives can be rapidly separated and identified.