Key result
A single-pill combination of atorvastatin/amlodipine reduced mean systolic blood pressure from 155.7 to 136.9 mm Hg and LDL cholesterol from 4.4 to 2.9 mmol/L at 3 months.
Why the study?
Does a single-pill combination of atorvastatin/amlodipine improve blood pressure and lipid profiles in patients with arterial hypertension, dyslipidemia, and moderate to high cardiovascular risk?
Observational (n=243)
Does a single-pill combination of atorvastatin/amlodipine improve blood pressure and lipid profiles in patients with arterial hypertension, dyslipidemia, and moderate to high cardiovascular risk?
A single-pill combination of atorvastatin and amlodipine effectively lowered both blood pressure and lipid levels over 3 months in patients with hypertension and dyslipidemia.
Answers are grounded in this paper and cite their sources.
May support SPC consideration in hypertension with dyslipidemia; hypothesis-generating pending randomized outcome trials.
- The aim was to evaluate the efficacy of a single-pill combination of atorvastatin/amlodipine in patients with arterial hypertension, dyslipidemia and moderate to high cardiovascular risk. This prospective study included 243 patients with arterial hypertension, dyslipidemia and moderate to high cardiovascular risk, mean age 63.3±9.8 years. All patients were prescribed a treatment with one of the following doses of a single-pill combination of atorvastatin/amlodipine: 10/5, 10/10, 20/5 or 20/10 mg daily. The follow-up period was 3 months. The mean baseline values of the systolic and diastolic blood pressure were 155.7±16.2 and 92.0±9.2 mm Hg, respectively. At month 3, the respective mean systolic and diastolic blood pressure values were 136.9±26.9 and 80.6±5.1 mm Hg. The mean baseline values of total cholesterol and low-density lipoprotein cholesterol were 6.6±1.2 and 4.4±1.1 mmol/L, respectively. At month 3, the respective mean values of total cholesterol and low-density lipoprotein cholesterol were 5.1±0.9 and 2.9±1.0 mmol/L. Treatment was discontinued in 9 (3.7%) patients due to adverse events. In conclusion, treatment with the single-pill combination of atorvastatin/amlodipine was effective and well tolerated by the patients with arterial hypertension, dyslipidemia and moderate to high cardiovascular risk.
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Stefan Naydenov (2018) conducted an observational in Arterial hypertension and dyslipidemia (n=243). Single-pill combination of atorvastatin/amlodipine was evaluated on Blood pressure and lipid levels at 3 months. A single-pill combination of atorvastatin/amlodipine reduced mean systolic blood pressure from 155.7 to 136.9 mm Hg and LDL cholesterol from 4.4 to 2.9 mmol/L at 3 months.
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