Why the study?
Does sertraline improve arousal and alertness in patients with severe traumatic brain injury and associated diffuse axonal injury?
RCT
placebo-controlled
randomized
No
Does sertraline improve arousal and alertness in patients with severe traumatic brain injury and associated diffuse axonal injury?
Answers are grounded in this paper and cite their sources.
Results of this RCT on sertraline remain unavailable; leaves open its effect on arousal in severe TBI with diffuse axonal injury.
Objective: To establish whether or not the serotonin reuptake inhibitor (SSRI) sertraline can improve arousal and alertness of patients with traumatic brain injury (TBI) and associated diffuse axonal injury (DAI). Serotonin is a major inhibitory as well an excitatory neurotransmitter, and serotonergic neurons modulate the activity of brain regions responsible for motor control, arousal, attention, and emotional regulation. Setting: Tertiary care inpatient rehabilitation centre directly attached to a university hospital level-one trauma centre. Design: Prospective placebo-controlled randomized trial utilizing sertraline on admission to acute rehabilitation. Data set
No takes yet. Share an insight, caveat, or question.
Lawrence Depalma Jay M. Meythaler (2001) conducted an RCT in traumatic brain injury (TBI) and associated diffuse axonal injury (DAI). sertraline vs. placebo was evaluated on arousal and alertness.
Synapse has enriched 10 related papers. Consider them for comparative context: