Why the study?
Does serum creatine kinase and lactate dehydrogenase isoenzyme determination detect early myocardial damage in patients with alcoholism?
Does serum creatine kinase and lactate dehydrogenase isoenzyme determination detect early myocardial damage in patients with alcoholism?
Serum creatine kinase and lactate dehydrogenase isoenzyme levels are not useful for the early detection of myocardial damage from alcohol.
Does not support isoenzyme testing for early myocardial injury in alcoholism; leaves open need for prospective validation.
Serum creatine kinase and lactate dehydrogenase isoenzymes were studied in 73 patients with alcoholism, including two patients with clinical alcoholic cardiomyopathy and 28 patients with haemodynamic evidence (systolic time interval abnormality) of disordered myocardial function. No isoenzyme abnormalities suggestive of myocardial injury were observed. We conclude that isoenzyme examination is unsuitable for the early detection of myocardial damage from alcohol.
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Fink et al. (1979) studied this question.
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