What question did this study set out to answer?

To examine cytokine production by peripheral blood monocytes and T cells during haematological recovery following intensive chemotherapy in patients with haematological malignancies.

January 1, 1993British Journal of Haematology

Cytokine production by peripheral blood monocytes and T cells during haemopoietic recovery after intensive chemotherapy

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Authors

YTYasushi TakamatsuNoguchi Thyroid Clinic and Hospital Foundation KAKoichi AkashiDartmouth College MHMine HaradaKyushu University

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Implication

Observational study reveals elevated haemopoietic cytokine production by monocytes and T cells in haematologic malignancy patients, suggesting active cellular involvement in post-chemotherapy...

Key Points

To examine cytokine production by peripheral blood monocytes and T cells during haematological recovery following intensive chemotherapy in patients with haematological malignancies.
Assessed 12 adults with haematological malignancies in complete remission receiving intensive consolidation chemotherapy alongside healthy controls.
Isolated peripheral blood monocytes and T cells during haematological recovery, cultured them for 24 hours in medium with 10% fetal calf serum, and quantified cytokine levels in supernatants and plasma using enzyme-linked immunosorbent assays.
Culture supernatants of recovery-phase monocytes contained significantly higher concentrations of IL-6, G-CSF, and IL-1 beta compared to monocytes from healthy controls.
Recovery-phase T cells produced significantly higher levels of GM-CSF and IFN-gamma than healthy T cells, accompanied by elevated circulating plasma levels of these cytokines.

Cite This Study

Takamatsu et al. (1993) studied this question.

synapsesocial.com/papers/6a9187ad9ea92d4f71f08d48 https://doi.org/10.1111/j.1365-2141.1993.tb04625.x

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Implication

Observational study reveals elevated haemopoietic cytokine production by monocytes and T cells in haematologic malignancy patients, suggesting active cellular involvement in post-chemotherapy...

Cytokine production by peripheral blood monocytes and T cells during haemopoietic recovery after intensive chemotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Cytokine production by peripheral blood monocytes and T cells during haemopoietic recovery after intensive chemotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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