Key result
The PTPN22 gene SNP1858 TT genotype was associated with a significantly higher susceptibility to primary immune thrombocytopenia compared to the CC genotype (OR 5.01).
Why the study?
The association between PTPN22 gene 1858 and 1123 single nucleotide polymorphisms and susceptibility to primary immune thrombocytopenia needed systematic evaluation.
Do PTPN22 gene SNP1858 and SNP1123 polymorphisms increase susceptibility to primary immune thrombocytopenia?
Meta-Analysis (n=3,044)
Do PTPN22 gene SNP1858 and SNP1123 polymorphisms increase susceptibility to primary immune thrombocytopenia?
Odds Ratio: 5.01 (95% CI 1.81–13.86)
p-value: p=0.002
PTPN22 gene SNP1858 and SNP1123 polymorphisms are associated with increased susceptibility to primary immune thrombocytopenia, suggesting a genetic basis for the disease.
PTPN22 SNPs may increase ITP susceptibility; leaves open need for larger, stable studies before any clinical application.
Objective: Systematic review of the association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene 1858 and 1123 sites single nucleotide polymorphism (SNP) with the susceptibility of primary immune thrombocytopenia (ITP). Method: Database searched includes PubMed, Embase, Web of Science, CNKI, CBM, VIP and WanFang Data. The retrieval period is from the establishment of the database to 30 June 2021. After screening articles according to inclusion and exclusion criteria, the data were extracted and methodological quality of the included studies was evaluated. Meta-analysis was performed using RevMan 5.4 and Stata 16.0 software. The combined OR value and its 95%CI were calculated. Sensitivity analysis and publication bias assessment were performed. Trial sequential analysis (TSA) was performed using TSA 0.9.5.10 Beta software. Results: A total of 10 studies with 10 articles were included, with a total of 932 cases and 2,112 controls. The results of meta-analysis showed that for SNP1858, the susceptibility of TT genotype to ITP was 5.01 times higher than CC genotype [95%CI (1.81, 13.86), p = 0.002]. For SNP1123, G allele carriers were more susceptible to ITP than C allele carriers [OR = 1.23, 95%CI (1.05, 1.45), p = 0.01], and GG genotype carriers were 1.51 times more susceptible to ITP than CC genotype carriers [95%CI (1.11, 2.06), p = 0.009]. Although the results are statistically significant, the results of sensitivity analysis showed certain limitations of stability, and the TSA analysis still indicated the possibility of false positive. No significant publication bias was observed. Conclusion: PTPN22 gene SNP1858 (rs2476601) and SNP1123 (rs2488457) polymorphisms are associated with susceptibility to primary immune thrombocytopenia. Due to the limitation of the number and quality of the included studies, the above conclusions need to be verified by more high-quality studies.
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Tian et al. (2022) conducted a meta-analysis in Primary immune thrombocytopenia (n=3,044). PTPN22 gene SNP1858 TT genotype vs. CC genotype was evaluated on Susceptibility to primary immune thrombocytopenia (OR 5.01, 95% CI 1.81, 13.86, p=0.002). The PTPN22 gene SNP1858 TT genotype was associated with a significantly higher susceptibility to primary immune thrombocytopenia compared to the CC genotype (OR 5.01).
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