Key result
Hypertensive chronic kidney disease was associated with increased oxidative stress, evidenced by elevated malondialdehyde levels, as well as dyslipidemia and thyroid dysfunction compared to healthy controls.
Why the study?
Chronic kidney disease is associated with complications including thyroid dysfunction, dyslipidaemia, hypertension, and high cardiovascular disease risk, with growing burden in developing nations.
Cross-Sectional (n=160)
No
Hypertensive CKD patients exhibit significantly higher oxidative stress, dyslipidemia, and thyroid dysfunction compared to healthy controls, highlighting the need for comprehensive metabolic monitoring to mitigate cardiovascular risk in this population.
Answers are grounded in this paper and cite their sources.
May support thyroid screening in CKD; leaves open need for prospective studies in developing nations.
CKD is a serious health problem worldwide. In developing nation, CKD has severe implication on health and economic output. The rapid increase of common risk factors such as hypertension (HTN), obesity and type 2 diabetes will result in greater burden on developing countries. There are many complications associated with CKD including thyroid dysfunction, dyslipidaemia, hypertension and cardiovascular disease (CVD). It is generally seen that patients suffering from CKD are at high risk of cardiovascular disease.
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Kaechawa et al. (2019) conducted a cross-sectional in Hypertensive Chronic Kidney Disease (n=160). Hypertensive Chronic Kidney Disease vs. Healthy controls was evaluated on Plasma Malondialdehyde (MDA) level (nmol/mL) (p=<0.001). Hypertensive chronic kidney disease was associated with increased oxidative stress, evidenced by elevated malondialdehyde levels, as well as dyslipidemia and thyroid dysfunction compared to healthy controls.
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