Key result
Surgical removal of a para-aortic multicentric paraganglioma in a 32-year-old pregnant woman normalized blood pressure and resolved brown adipose tissue hypermetabolism on follow-up FDG PET.
Case Report (n=1)
18F-FDG PET/CT can detect brown adipose tissue hyperactivation associated with pregnancy and paraganglioma, which resolves upon tumor resection.
May support FDG PET monitoring of BAT activation in rare paraganglioma cases; leaves open broader utility without prospective data.
This 32-year-old woman presented with pregnancy-related arterial hypertension unresponsive to antihypertensive therapy. During cesarean delivery, a lobulated retroperitoneal mass was discovered. F-FDG PET/CT performed 18 days postpartum demonstrated the hyperactive retroperitoneal mass and extensive hyperactivated brown adipose tissue. The mass was surgically removed, revealing a para-aortic multicentric paraganglioma. After surgery, blood pressure normalized, and serum chromogranin A and urinary metanephrines normalized. Brown adipose tissue hypermetabolism disappeared on follow-up FDG PET. Her initial FDG PET demonstrated brown adipose tissue hyperactivation, which may have been caused by the combination of hormonal changes in pregnancy and the paraganglioma.
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Maffione et al. (2017) conducted a case report in Pregnancy-related arterial hypertension and paraganglioma (n=1). Surgical removal of paraganglioma was evaluated on Normalization of blood pressure, serum chromogranin A, urinary metanephrines, and resolution of brown adipose tissue hypermetabolism. Surgical removal of a para-aortic multicentric paraganglioma in a 32-year-old pregnant woman normalized blood pressure and resolved brown adipose tissue hypermetabolism on follow-up FDG PET.
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