Why the study?
Does DX-9065a prevent thrombus formation without prolonging bleeding time compared to other anticoagulants in rat models of thrombosis?
Does DX-9065a prevent thrombus formation without prolonging bleeding time compared to other anticoagulants in rat models of thrombosis?
Direct and selective inhibition of factor Xa by DX-9065a effectively prevents thrombosis without compromising primary hemostasis in rat models.
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Selective factor Xa inhibition may dissociate antithrombotic from antihemostatic effects in preclinical models; leaves open clinical translation.
Morishima et al. (1997) studied this question.
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