Key result
Postoperative administration of edoxaban in patients undergoing lower extremity orthopedic surgery resulted in a low overall symptomatic DVT incidence of 0.6%, with no major bleeding events.
Why the study?
Does postoperative edoxaban prevent symptomatic DVT in patients undergoing orthopedic lower extremity surgery?
Observational (n=500)
Does postoperative edoxaban prevent symptomatic DVT in patients undergoing orthopedic lower extremity surgery?
Postoperative edoxaban administration appears safe and effective for preventing symptomatic DVT after orthopedic lower extremity surgery, with an incidence of 4.6% post-TKA and 0% post-hip surgery.
Edoxaban may warrant consideration post-orthopedic surgery; leaves open confirmation of efficacy and safety in randomized trials.
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Nakai et al. (2017) conducted an observational in Orthopedic surgery of the lower extremity (n=500). Edoxaban was evaluated on Incidence of symptomatic deep vein thrombosis (DVT). Postoperative administration of edoxaban in patients undergoing lower extremity orthopedic surgery resulted in a low overall symptomatic DVT incidence of 0.6%, with no major bleeding events.
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