Key result
The GPIa 807T allele was not associated with an increased risk of myocardial infarction (OR 0.88; 95% CI 0.74-1.05; P=0.17).
Why the study?
Does the GPIa 807T allele increase the risk of myocardial infarction in adults aged <75 years?
Population
1,053 individuals aged <75 years, comprising 546 acute myocardial infarction cases and 507 controls
Comparison
Presence of the GPIa 807T allele vs Absence of the GPIa 807T allele / Control group
Design
Case-control
Authors
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No association of GPIa 807T with MI risk in case-control data; leaves open whether other platelet receptor variants influence thrombosis.
Case-Control (n=1,053)
Does the GPIa 807T allele increase the risk of myocardial infarction in adults aged <75 years?
Odds Ratio: 0.88 (95% CI 0.74–1.05)
p-value: p=0.17
The GPIa C807T dimorphism, which is associated with platelet collagen receptor density, is not a significant genetic risk factor for myocardial infarction.
Croft et al. (1999) conducted a case-control in Myocardial infarction (n=1,053). GPIa 807T allele vs. Non-carriers was evaluated on Myocardial infarction (OR 0.88, 95% CI 0.74-1.05, p=0.17). The GPIa 807T allele was not associated with an increased risk of myocardial infarction (OR 0.88; 95% CI 0.74-1.05; P=0.17).
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