Key result
Infusion of the GPIIb-IIIa antagonist Ro 44-9883 increased postchamber fibrinopeptide A levels (203 vs 95 ng/mL) by leaving the procoagulant collagen-adherent platelet layer intact.
Absolute Event Rate: 203% vs 95%
Collagen-adherent platelets promote coagulation during early thrombogenesis by providing assembly sites for the factor X activation complex.
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May inform antithrombotic targeting of adherent platelets; leaves open in vivo translation and clinical relevance.
Kirchhofer et al. (1995) studied this question. Ro 44-9883 (GPIIb-IIIa antagonist) vs. Control without inhibitor was evaluated on Postchamber fibrinopeptide A (FPA) levels. Infusion of the GPIIb-IIIa antagonist Ro 44-9883 increased postchamber fibrinopeptide A levels (203 vs 95 ng/mL) by leaving the procoagulant collagen-adherent platelet layer intact.
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