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December 1, 1993Journal of Clinical InvestigationOpen Access

Studies of activated GPIIb/IIIa receptors on the luminal surface of adherent platelets. Paradoxical loss of luminal receptors when platelets adhere to high density fibrinogen.

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Population

Platelets obtained from 8 separate human donors

Comparison

Adhesion to high-density fibrinogen vs Adhesion to low-density fibrinogen or collagen

Design

Preclinical

Authors

BCBS CollerBrigham and Women's Hospital JKJL KutokState University of New York LSL E ScudderUniversity of Vermont

Discussion

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Implication

Should not yet influence antiplatelet strategies; leaves open translational relevance of fibrinogen-density effects to human thrombosis.

Structured PICO

P

Population

Platelets obtained from 8 separate human donors

I

Intervention

Adhesion to high-density fibrinogen

C

Comparator

Adhesion to low-density fibrinogen or collagen

O

Outcome

Accessibility of activated, luminal GPIIb/IIIa receptors assessed by thromboerythrocyte bindingsurrogate

Platelets adherent to high-density fibrinogen paradoxically lose accessible luminal GPIIb/IIIa receptors, which may limit further platelet recruitment and thrombus formation.

Cite This Study

Coller et al. (1993) studied this question.

synapsesocial.com/papers/6a764c565b340c7cf606db5b https://doi.org/10.1172/jci116899

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets1985 · 22 citations
2Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.1987 · 179 citations
3Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins1989 · 301 citations
4Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes. A new approach to platelet activation and recruitment.1991 · 243 citations
5The human fibroblast class II extracellular matrix receptor mediates platelet adhesion to collagen and is identical to the platelet glycoprotein Ia-IIa complex.1988 · 256 citations