Key result
Permanently adhered platelets showed markedly enhanced procoagulant activity compared with platelets in suspension, with collagen supporting up to 5 times more soluble thrombin formation than clots.
Platelet adhesion to collagen or preformed clots markedly enhances procoagulant activity and thrombin generation through distinct mechanisms involving microparticle formation.
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New assay enables controlled platelet PCA measurement; leaves open clinical translation pending validation.
Ilveskero et al. (2001) studied this question. Platelet adhesion on collagen or plasma clots vs. Platelets in suspension was evaluated on Platelet procoagulant activity (PCA) and thrombin generation. Permanently adhered platelets showed markedly enhanced procoagulant activity compared with platelets in suspension, with collagen supporting up to 5 times more soluble thrombin formation than clots.
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