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January 1, 1977Thrombosis and Haemostasis

Platelet Interaction with Collagen Fibrils in Flowing Blood

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Population

Rabbit aorta subendothelium and alpha chymotrypsin-digested subendothelium exposed to anticoagulated human…

Comparison

Alpha chymotrypsin-digested subendothelium vs Intact subendothelium

Design

Preclinical

Follow-up

2.5 to 40 minutes

Authors

HBHans R. Baumgartner

Discussion

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Overview

Fibrillar collagen may enhance mural thrombus growth in animal flow models; leaves open relevance to human arterial thrombosis mechanisms.

Structured PICO

P
Population
Rabbit aorta subendothelium and alpha chymotrypsin-digested subendothelium exposed to anticoagulated human blood in an annular flow chamber
I
Intervention
Alpha chymotrypsin-digested subendothelium (fibrillar collagen meshwork)
C
Comparator
Intact subendothelium
O
Outcome
Rate of platelet adhesion, rate of aggregation, and mural thrombi formationsurrogate

Fibrillar collagen of alpha chymotrypsin-digested subendothelium provides a more thrombogenic surface for flowing blood compared to intact subendothelium due to increased platelet aggregation.

Cite This Study

Hans R. Baumgartner (1977) studied this question.

synapsesocial.com/papers/6a72425bc1a24a6142dbd203https://doi.org/10.1055/s-0038-1649196
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Upstream Thrombus Growth Impairs Downstream Thrombogenesis in Non-Anticoagulated Blood: Effect of Procoagulant Artery Subendothelium and Non-Procoagulant Collagen1991 · 24 citations
  2. 2Role of collagen-adherent platelets in mediating fibrin formation in flowing whole blood1995 · 51 citations
  3. 3The effect of pretreatment of human or rabbit platelets with chymotrypsin on their responses to human fibrinogen and aggregating agents1979 · 83 citations
  4. 4Platelet Adhesion and Aggregation Dynamics over Collagen- and VWF-coated Surfaces: Insights from Dissipative Particle Dynamics Simulations and Microfluidic Experiments2026 · 2 citations
  5. 5Modified platelet deposition on matrix metalloproteinase 13 digested collagen I2015 · 13 citations