What is the clinical evidence from this study?

Study design: Other. Intervention: Blood flow (shear rates of 50, 650, and 2,600 s-1) vs. Different shear rates and surfaces. Primary outcome: Thrombin generation, fibrin formation, and fibrin deposition (p=<.01).

What does this research mean for the field?

Thrombin generation and thrombus composition are strongly regulated by blood flow shear rates in a manner dependent on the thrombogenic surface, with low shear favoring fibrin deposition on endothelial cells and high shear favoring platelet-rich thrombi on collagen. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

October 1, 1994Blood

Effect of blood flow on thrombin generation is dependent on the nature of the thrombogenic surface

Q: What are the key findings of this study?

Thrombin formation is strongly influenced by blood flow and surface composition, with fibrin deposition on procoagulant endothelial cells correlating positively with F 1+2 and T-AT levels (P<0.01).

Q: What does this research mean for the field?

Thrombin generation and thrombus composition are strongly regulated by blood flow shear rates in a manner dependent on the thrombogenic surface, with low shear favoring fibrin deposition on endothelial cells and high shear favoring platelet-rich thrombi on collagen. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

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Key result

Blood flow and surface composition strongly influence thrombin formation and correlate with endothelial fibrin deposition.

P<.01

Population

Nonanticoagulated human blood drawn from an antecubital vein

Comparison

Perfusion over stimulated endothelial cells… vs Comparison between different shear rates and…

Design

Preclinical

Follow-up

5 minutes

Authors

ADArmelle DiquélouÉcole Nationale Vétérinaire de Toulouse SLSylvie LemozyHôpital Rangueil DDD. DupouyWisconsin Parkinson Association

Discussion

Member takes

Implication

Animal data link flow and surface to thrombin; leaves open relevance to human antithrombotic strategies.

Structured PICO

Population

Nonanticoagulated human blood drawn from an antecubital vein

Exposure

Perfusion over stimulated endothelial cells expressing tissue factor or human type III collagen fibrils at shear rates of 50, 650, and 2,600 s-1

Comparator

Comparison between different shear rates and different thrombogenic surfaces

Outcome

Deposition of platelets and fibrin (measured by morphometry) and thrombin/fibrin formation (measured by F 1 + 2, T-AT, and FPA in blood effluent)surrogate

Main Result

p-value: p=<.01

Thrombin generation is highly dependent on both blood flow shear rate and the specific composition of the thrombogenic surface.

Cite This Study

Diquélou et al. (1994) studied this question. Blood flow (shear rates of 50, 650, and 2,600 s-1) vs. Different shear rates and surfaces was evaluated on Thrombin generation, fibrin formation, and fibrin deposition (p=<.01). Thrombin formation is strongly influenced by blood flow and surface composition, with fibrin deposition on procoagulant endothelial cells correlating positively with F 1+2 and T-AT levels (P<0.01).

synapsesocial.com/papers/6aa607cc39a5015a928e485c https://doi.org/10.1182/blood.v84.7.2206.2206

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Effect of blood flow on thrombin generation is dependent on the nature of the thrombogenic surface

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Effect of blood flow on thrombin generation is dependent on the nature of the thrombogenic surface

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider