Key result
Increasing shear rate drives a ~12-fold increase in platelet deposition on altered arterial surfaces.
Why the study?
Alterations in arterial blood flow are thought to predispose to thrombus formation, but the exact relationships have not been fully elucidated.
Does shear rate affect platelet and fibrin deposition on altered arterial surfaces?
Population
Partially denuded rabbit aortas perfused with fresh nonanticoagulated human blood
Comparison
Varying shear rates from zero to 1500 sec-1
Design
In vitro recirculating apparatus study
Follow-up
3 minutes
Authors
Loading...
In vitro shear-dependent platelet/fibrin deposition on denuded surfaces warrants prospective flow studies; leaves open any clinical thrombosis modulation strategy.
Does shear rate affect platelet and fibrin deposition on altered arterial surfaces?
p-value: p=<0.05
Higher shear rates significantly increase platelet and fibrin deposition on altered arterial surfaces in an ex vivo model.
Ouriel et al. (1991) studied Thrombus formation. Varying shear rates (0 to 1500 sec-1) vs. Zero shear rate was evaluated on Platelet and fibrin deposition (p=<0.05). Increasing shear rate from zero to 1500 sec-1 significantly increased platelet deposition (from 5.2 to 64.7 x 10^6 platelets/cm2) and fibrin deposition on altered arterial surfaces (p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: