Blood shear rate and corresponding shear stress play an essential role in arterial thrombus formation and influence the efficacy of antithrombotic agents.
How does blood shear rate impact arterial thrombus formation and the efficacy of antithrombotic agents?
Blood shear rate is a critical determinant of arterial thrombus formation and antithrombotic drug efficacy, suggesting a need for shear-dependent point-of-care monitoring.
The shear rate and corresponding shear stress have impacts on arterial thrombus formation. In particular, the effects of increasing concentration of platelets at the vessel wall and activation of platelets at this site increase the growth and stability of the thrombi which may result in a fatal narrowing of the arterial lumen. The efficacy of many antithrombotic agents is shear dependent as well. It is apparent that there is a need for a point-of-care device to rapidly monitor the risk for arterial thrombosis and to optimize antithrombotic therapy in vitro. The present review focuses on the essential role of shear rate on arterial thrombus formation in native human blood drawn directly from an antecubital vein.
Sakaríassen et al. (Thu,) conducted a review in Arterial thrombosis. Blood shear rate was evaluated on Arterial thrombus formation. Blood shear rate and corresponding shear stress play an essential role in arterial thrombus formation and influence the efficacy of antithrombotic agents.
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