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June 1, 2000Arteriosclerosis Thrombosis and Vascular Biology

Platelet Thrombus Formation on Collagen at High Shear Rates Is Mediated by von Willebrand Factor–Glycoprotein Ib Interaction and Inhibited by von Willebrand Factor–Glycoprotein IIb/IIIa Interaction

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Population

Blood from patients with severe von Willebrand's disease or normal blood reconstituted with a human albumin…

Comparison

Mutant forms of von Willebrand Factor lacking… vs Normal blood or experimental conditions where…

Design

Preclinical

Authors

YWYaping WuSichuan UniversityTVTom VinkGenmab (Netherlands)MSMarion E. SchiphorstUtrecht University

Discussion

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Overview

vWF A1-domain blockade abolishes high-shear thrombosis in models; hypothesis-generating for targeted antithrombotics pending human validation.

Structured PICO

P
Population
Blood from patients with severe von Willebrand's disease (vWD) or normal blood reconstituted with a human albumin solution instead of plasma
I
Intervention
Mutant forms of von Willebrand Factor (vWF) lacking interaction with either glycoprotein Ib (DeltaA1-vWF) or glycoprotein IIb/IIIa (Arg-Gly-Gly-Ser-vWF) added to the perfusate
C
Comparator
Normal blood or experimental conditions where both vWF and fibrinogen are present as ligands
O
Outcome
Platelet thrombus formation on collagen type III at shear rates of 300, 800, and 2600 s(-1)surrogate

Platelet thrombus formation at high shear rates requires vWF-GpIb interaction and is modulated by vWF-glycoprotein IIb/IIIa interaction, which competes with fibrinogen.

Cite This Study

Wu et al. (2000) studied this question.

synapsesocial.com/papers/6a70dca1febe604dd709a202https://doi.org/10.1161/01.atv.20.6.1661
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation1992 · 235 citations
  2. 2Contribution of Distinct Adhesive Interactions to Platelet Aggregation in Flowing Blood1999 · 265 citations
  3. 3A3 Domain Is Essential for Interaction of von Willebrand Factor with Collagen Type III1996 · 153 citations
  4. 4Fibronectin in platelet adhesion to human collagen types I and III. Use of nonfibrillar and fibrillar collagen in flowing blood studies.1988 · 39 citations
  5. 5Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.1998 · 289 citations