Why the study?
Do polymeric aurin tricarboxylic acid and recombinant vWF fragment prevent shear-dependent thrombus formation in vitro?
Population
In vitro models using whole blood and platelet-rich-plasma to simulate arterial platelet thrombus formation…
Design
Preclinical
Authors
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Inhibits shear-dependent thrombosis in vitro; hypothesis-generating for vWF-targeted antithrombotics, pending in vivo validation.
Do polymeric aurin tricarboxylic acid and recombinant vWF fragment prevent shear-dependent thrombus formation in vitro?
Inhibitors of von Willebrand factor binding to platelets, such as ATA and rvWF445-733, effectively block shear-dependent arterial thrombus formation in vitro.
Alevriadou et al. (1993) studied this question.
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