Key result
Compared with physiological low wall shear rates, pathological high wall shear rates (2,500-5,000 s-1) caused thicker and more easily shed thrombi with more condensed cores.
Population
Whole blood from 20 healthy volunteers perfused over collagen- or vWF-coated microfluidic channels.
Comparison
Exposure to various wall shear rates ranging… vs Comparison across different wall shear rates.
Design
Preclinical
Authors
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High shear yields unstable thrombi in animals; leaves open relevance to human embolization.
Pathological high shear rates induce the formation of thicker, more densely packed platelet thrombi that are prone to shedding, driven by an attachment-detachment balance.
Shi et al. (2016) studied Healthy volunteers (n=20). Pathological high wall shear rates (2,500-5,000 s-1) vs. Physiological low/moderate wall shear rates (125-1,500 s-1) was evaluated. Compared with physiological low wall shear rates, pathological high wall shear rates (2,500-5,000 s-1) caused thicker and more easily shed thrombi with more condensed cores.
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