Key result
Higher wall shear rate, red cell, and platelet concentrations increase in vitro thrombus formation.
Why the study?
The influence of rheological factors on platelet interaction with vessel surfaces under controlled flow conditions was not fully characterized.
Population
In vitro perfusion system using subendothelium from rabbit aorta exposed to blood
Comparison
Effects of varying wall shear rate, red cell concentration, platelet concentration, and axial distance
Design
Preclinical in vitro experimental study
Authors
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May inform shear-dependent thrombosis risk assessment; hypothesis-generating and should not yet change practice.
Rheological factors, including wall shear rate and red cell concentration, play a critical role in mediating platelet adhesion and thrombus formation on subendothelial surfaces.
Turitto et al. (1979) studied this question. Controlled flow conditions was evaluated on Platelet adhesion and thrombus formation. In an in vitro perfusion system, platelet adhesion and thrombus formation increased with wall shear rate, red cell concentration, and platelet concentration.
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