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Avian coronavirus strain Italy 02, recently identified in Morocco, has caused substantial economic losses in the poultry sector. This study evaluated the efficacy of the live attenuated Mass-type H120 vaccine against this strain in broiler chickens. Ninety specific pathogen-free chicks were allocated to three groups: singly vaccinated, unvaccinated challenged, and unvaccinated controls. Three weeks after vaccination, all groups were exposed to the Italy 02 virus. Vaccinated birds exhibited minimal clinical signs, with only mild conjunctivitis observed in a few cases. No significant histopathological lesions were detected in the tracheas of birds receiving two doses. Virus re-isolation was markedly reduced in twice-vaccinated birds (10%) in comparison with those vaccinated once (50%). Vaccination, particularly with two doses, significantly enhanced the antibody response and inhibited viral replication. These results suggest that the H120 vaccine is a promising option for controlling the spread of this emergent avian coronavirus in Morocco.
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Khataby et al. (2025) studied this question.