Key result
Thiorphan increased plasma irANP (+118%) and CBSA (+30-100%) during volume expansion, whereas atrial appendectomy reduced irANP (-80%) and CBSA (-30 to -80%) (P<=0.05).
Why the study?
Does endogenous ANP modulation via thiorphan or atrial appendectomy affect plasma protein extravasation during acute intravascular volume expansion in rats?
Does endogenous ANP modulation via thiorphan or atrial appendectomy affect plasma protein extravasation during acute intravascular volume expansion in rats?
p-value: p=<=0.05
Endogenous ANP increases plasma protein extravasation independent of volume and pressure disturbances during acute intravascular expansion.
Endogenous ANP may increase protein extravasation during volume expansion in rats; hypothesis-generating with no clinical translation.
The effects of endopeptidase inhibition and right atrial appendectomy (AA) on plasma immunoreactive atrial natriuretic peptide (irANP) concentrations and extravascular accumulation of 131I-labeled bovine serum albumin (CBSA) during volume expansion (VE) were examined in pentobarbital sodium-anesthetized rats (n = 5 per group). Compared with controls, infusion of isoncotic albumin (30 ml/kg) increased central venous pressure (CVP) by 5.5 mmHg, plasma irANP by 7-fold, and CBSA in multiple tissues by 1.6- to 4-fold (P < or = 0.05). Inhibition of ANP metabolism with thiorphan (40 mg/kg) had no effect in control animals but increased plasma irANP (+118%) and CBSA (+30-100%) compared with VE alone (P < or = 0.05). Likewise, interference with ANP release by AA reduced plasma irANP (-80%) and CBSA (-30 to -80%) response to VE in parallel (P < or = 0.05). The peak increase in CVP during VE was not affected by either of these manipulations. It is concluded that endogenous ANP increases plasma protein extravasation independent of volume and pressure disturbances during acute intravascular expansion.
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V. L. Tucker (1996) studied this question. Thiorphan and right atrial appendectomy vs. Controls (volume expansion alone) was evaluated on Plasma immunoreactive atrial natriuretic peptide (irANP) concentrations and extravascular accumulation of 131I-labeled bovine serum albumin (CBSA) (p=<=0.05). Thiorphan increased plasma irANP (+118%) and CBSA (+30-100%) during volume expansion, whereas atrial appendectomy reduced irANP (-80%) and CBSA (-30 to -80%) (P<=0.05).
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