Why the study?
Does oral DMP728 prevent carotid artery thrombosis in a canine model?
Population
Anesthetized dogs in an electrically induced carotid artery thrombosis model
Comparison
DMP728 administered 120 minutes prior to… vs Saline
Design
Preclinical
Follow-up
180 minutes
Authors
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Animal data on oral DMP728 support further antithrombotic development; leaves open translation to human carotid thrombosis prevention.
Does oral DMP728 prevent carotid artery thrombosis in a canine model?
Oral administration of the GPIIb/IIIa antagonist DMP728 effectively prevents carotid artery occlusive thrombosis in a canine model without altering hemodynamics.
Mousa et al. (1997) studied this question.
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