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May aid ICU acid-base interpretation; leaves open prospective outcome trials before practice change.
A quantitative physical chemical analysis of acid-base physiology is gaining acceptance among intensivists because of its ability to explain acid-base dilemmas seen in the intensive care unit and not well addressed by the traditional approaches. Also, this approach has utility in exploring unexplained anio-ninduced acidosis in which the familiar anion gap is insufficient or inaccurate. The key features of this approach are 1) application of accepted physical chemical principles, 2) identification of independent and dependent acid-base variables, and 3) emphasis on water dissociation as the source of free hydrogen ions in aqueous solutions
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John A. Kellum (1997) studied this question.
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