What is the clinical evidence from this study?

Intervention: Stimulation of central chemoreceptors and arterial baroreceptors. Primary outcome: Cross-correlation analysis of RTN-pF and Böt-VRG neuron pairs.

What question did this study set out to answer?

To investigate whether local connections within the retrotrapezoid-parafacial region and projections from the caudal ventral respiratory column modulate respiratory firing patterns and chemoreceptive responses.

March 10, 2011Journal of Neurophysiology

Ventrolateral medullary functional connectivity and the respiratory and central chemoreceptor-evoked modulation of retrotrapezoid-parafacial neurons

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Key result

Local RTN-pF neuron interactions and inputs from Böt-VRG neurons jointly contribute to respiratory modulation of RTN-pF neuronal discharge patterns.

Population

14 decerebrate, vagotomized cats

Design

Preclinical

Authors

MOMackenzie M. OttUniversity of South Florida SNSarah C. NudingUniversity of South Florida LSLauren S. SegersUniversity of South Florida

Discussion

Member takes

Implication

Hypothesis-generating for brainstem respiratory circuitry in rodents; leaves open translation to human cardiorespiratory control.

Key Points

To investigate whether local connections within the retrotrapezoid-parafacial region and projections from the caudal ventral respiratory column modulate respiratory firing patterns and chemoreceptive responses.
Recorded extracellular spike trains from 294 retrotrapezoid-parafacial and 490 Bötzinger-ventral respiratory group neurons alongside phrenic nerve activity in 14 decerebrate, vagotomized cats using multielectrode arrays.
Categorized neuronal responses following sequential, transient stimulation of central chemoreceptors via CO2/pH changes and arterial baroreceptors.
Conducted cross-correlation analysis on 2,884 intra-regional and 8,490 inter-regional neuron pairs to detect paucisynaptic excitatory and inhibitory interactions.
Respiratory modulation was present in 214 retrotrapezoid-parafacial neurons (72.8%) and 398 Bötzinger-ventral respiratory group neurons (81.2%), while 124 and 95 neurons exhibited cardiac modulation, respectively.
Short-time scale functional correlations occurred in 174 retrotrapezoid-parafacial neurons (59.5%), with 49 trigger neurons producing 99 correlograms with offset peaks or troughs indicating local synaptic excitation or inhibition.
Forty-nine Bötzinger-ventral respiratory group neurons (10.0%) served as triggers in 74 correlograms with offset features targeting retrotrapezoid-parafacial neurons, confirming convergent functional inputs from caudal respiratory circuits.

Structured PICO

Population

14 decerebrate, vagotomized cats in which spike trains from RTN-pF and Böt-VRG neurons were monitored.

Intervention

Sequential, selective, transient stimulation of central chemoreceptors and arterial baroreceptors

Outcome

Change in firing rate following stimulus and cross-correlation analysis of neuron pairssurrogate

Local RTN-pF neuron interactions and inputs from Böt-VRG neurons jointly contribute to respiratory modulation of RTN-pF neuronal discharge patterns.

Cite This Study

Ott et al. (2011) studied this question. Stimulation of central chemoreceptors and arterial baroreceptors was evaluated on Cross-correlation analysis of RTN-pF and Böt-VRG neuron pairs. Local RTN-pF neuron interactions and inputs from Böt-VRG neurons jointly contribute to respiratory modulation of RTN-pF neuronal discharge patterns.

synapsesocial.com/papers/6a918d5d9cd6bcde3cfb61ed https://doi.org/10.1152/jn.00262.2010

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Ventrolateral medullary functional connectivity and the respiratory and central chemoreceptor-evoked modulation of retrotrapezoid-parafacial neurons

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Ventrolateral medullary functional connectivity and the respiratory and central chemoreceptor-evoked modulation of retrotrapezoid-parafacial neurons

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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