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The effect of 17β-estradiol benzoate (E2 B) treatment on serum LH and FSH concentrations and the acute response of serum testosterone concentrations have been examined in intact adult male rats. E2 B treatment (100 µg/day for 3 days) did not alter serum LH concentration or testes weights but did lower FSH levels in 1 of 2 experiments. E2 B treatment significantly decreased ventral prostate weights and serum testosterone concentrations. Acute treatment with NIH-LH-B9 (1–100 µg) resulted in significant increases in serum testosterone in both E2 B treated and control rats but at all doses tested the serum testosterone concentrations obtained in E2 B treated animals were significantly less than in control animals. This work supports the hypothesis that estradiol has a direct inhibitory effect on testosterone secretion.
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William H. Moger (1976) studied this question.
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