Key result
Heart rate fragmentation increases monotonically with age and is significantly associated with major incident cardiovascular events, adding predictive value to standard cardiovascular risk indices.
Why the study?
This perspectives article discusses the use of heart rate fragmentation, a novel dynamical biomarker of altered sinoatrial pacemaker-neuroautonomic function, to assess biological versus chronological age.
Heart rate fragmentation is proposed as a novel dynamical biomarker to assess biological aging and improve cardiovascular risk prediction.
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Hypothesis-generating for HRF-based biological age assessment; leaves open clinical utility pending prospective validation.
Costa et al. (2019) conducted a review in Biological aging and cardiovascular risk. Heart rate fragmentation was evaluated. Heart rate fragmentation increases monotonically with age and is significantly associated with major incident cardiovascular events, adding predictive value to standard cardiovascular risk indices.
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