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ISULFITE is employed as a preservative in foods and pharmaceuticals.Chemical studies of its interactions with nucleic acid components indicate that it reacts with uracil and cytosine in ways which might be mutagenic ( SHAPIRO and WEISGRAS 1970;SHAPIRO, COHEN and SERVIS 1970;HAYATSU et at. 1970).Two preliminary assays, one in the bacterium Escherichia coli (MUKAI, HAWRYLUK and SHAPIRO 1970) and one in bacteriophage lambda (HAYATSU and MIURA 1970), revealed some bisulfite mutagenicity.In both instances, however, a maximum mutagenic response was observed within very short treatment intervals, no further mutagenicity being observed thereafter.The results with E. coti showed
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Summers et al. (1971) studied this question.
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