Key result
Catheter-directed thrombolysis plus anticoagulation significantly increased the rate of improvement in the RV/LV ratio at 1 week compared to anticoagulation alone (34.0% vs. 19.4%, P<0.001).
Why the study?
The optimal treatment strategy for intermediate-risk pulmonary embolism remains controversial, and the short-term efficacy and safety of catheter-directed thrombolysis remain incompletely defined.
Does catheter-directed thrombolysis plus anticoagulation improve right ventricular function compared to anticoagulation alone in patients with acute intermediate-risk pulmonary embolism?
Population
89 patients diagnosed with acute intermediate-risk PE
Comparison
CDT plus anticoagulation vs anticoagulation alone
Design
Retrospective study
Follow-up
1 week primary outcome, 3-month follow-up period for bleeding
Authors
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May support faster short-term RV recovery with CDT in intermediate-risk PE; leaves open need for RCTs on hard clinical outcomes.
Cohort (n=89)
Does catheter-directed thrombolysis plus anticoagulation improve right ventricular function compared to anticoagulation alone in patients with acute intermediate-risk pulmonary embolism?
Absolute Event Rate: 34% vs 19.4%
p-value: p=<0.001
Catheter-directed thrombolysis plus anticoagulation provides more rapid short-term improvement in right ventricular function compared to anticoagulation alone in acute intermediate-risk pulmonary embolism, without a statistically significant increase in bleeding.
Zhang et al. (2026) conducted a cohort in Acute intermediate-risk pulmonary embolism (n=89). Catheter-directed thrombolysis (CDT) plus anticoagulation vs. Anticoagulation alone was evaluated on Rate of improvement in the RV/LV ratio at 1 week vs. baseline (p=<0.001). Catheter-directed thrombolysis plus anticoagulation significantly increased the rate of improvement in the RV/LV ratio at 1 week compared to anticoagulation alone (34.0% vs. 19.4%, P<0.001).
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