Key result
Among 40 patients with portopulmonary hypertension, the condition was most frequently caused by congenital portocaval shunts or viral/toxic cirrhosis, with 90% of patients presenting at intermediate or high mortality risk.
Why the study?
The study was conducted to review the clinical, functional, and hemodynamic status of patients with portopulmonary hypertension.
Observational (n=40)
No
Portopulmonary hypertension is most commonly seen in middle-aged women and often presents with intermediate to high clinical risk profiles.
Answers are grounded in this paper and cite their sources.
Observational portopulmonary hypertension data warrant cautious clinical interpretation; leaves open need for prospective validation.
Aim. Review of clinical, functional and hemodynamic status of patients with portopulmonary hypertension Materials and methods. Clinical cases of 40 patients with portopulmonary hypertension, who hospitalized in the department of pulmonary hypertension and heart diseases of the National Medical Research Centre of cardiology named after academician E.I. Chazov of Ministry of Health in the period from 2015 to 2024 years. We have analyzed clinical, functional, hemodynamic parameters. Results. 40% of patients were men, mean age 52.6±9.7 years. More often Reasons of portopulmonary hypertension of our patients were congenital portocaval shunts, virus or toxic cirros. The time from the diagnosis of portal hypertension to the start of PAH symptoms was 3±2.8 years. Median level NT-proBNP was 526.60 pkg/mL, D-dimer 0.44.35% and 55% of these patients belonged to the high and intermediate risk groups, respectively. The mean distance in the six minute walk test was 406.8±109.2m, functional class II. Conclusion. The occurrence of portal hypertension can be caused by various reasons. This diagnosis is more often found in middle-aged women. Further dynamic monitoring of these patients will improve their clinical status and determine their prognosis.
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Barkovskaya et al. (2025) conducted an observational in Portopulmonary hypertension (n=40). Portopulmonary hypertension was evaluated on Clinical, functional, and hemodynamic profile. Among 40 patients with portopulmonary hypertension, the condition was most frequently caused by congenital portocaval shunts or viral/toxic cirrhosis, with 90% of patients presenting at intermediate or high mortality risk.
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