Key result
Hypoxia augmented left ventricular twist compared with baseline (19.6° vs 14.8°; P<0.001) via β1-adrenergic-dependent and independent mechanisms, without evidence of endocardial dysfunction.
Why the study?
The mechanisms underlying augmented LV twist mechanics during acute and chronic hypoxemia, and whether hypoxia produces masked subendocardial dysfunction, remain unknown.
Does esmolol infusion alter left ventricular twist mechanics in males exposed to acute and chronic hypoxia?
RCT (n=12)
Double-blind
randomized
Does esmolol infusion alter left ventricular twist mechanics in males exposed to acute and chronic hypoxia?
Absolute Event Rate: 19.6% vs 14.8%
p-value: p=<0.001
Left ventricular twist is augmented in hypoxia via both β1-adrenergic-dependent and independent mechanisms, without evidence of endocardial dysfunction.
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LV twist augmentation in hypoxia reflects adaptive β1-AR–dependent and independent mechanisms without endocardial dysfunction; extends mechanistic understanding in healthy subjects.
Williams et al. (2019) reported an RCT. Esmolol and hypoxia vs. Volume-matched saline and normoxia was evaluated on Left ventricular twist (p=<0.001). Hypoxia augmented left ventricular twist compared with baseline (19.6° vs 14.8°; P<0.001) via β1-adrenergic-dependent and independent mechanisms, without evidence of endocardial dysfunction.
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