Key result
Among 96 patients with influenza A without cardiac symptoms, 11.4% had elevated serum myosin light chain I concentrations, suggesting the presence of asymptomatic myocardial injury.
Why the study?
Does influenza infection cause asymptomatic myocardial injury as measured by elevated serum myosin light chain I in patients without apparent clinical myocardial injury?
Observational (n=96)
No
Does influenza infection cause asymptomatic myocardial injury as measured by elevated serum myosin light chain I in patients without apparent clinical myocardial injury?
Influenza A infection may cause asymptomatic myocardial injury, as evidenced by elevated serum myosin light chain I in over 10% of patients without cardiac symptoms.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for asymptomatic myocardial injury in influenza A; prospective studies needed to determine clinical relevance.
OBJECTIVE: Myocarditis has been described as a complication of influenza. Patients with influenza may have symptoms and abnormal laboratory data (including chest X-ray, electrocardiogram, etc.) suggestive of myocarditis, although few observations have been made regarding the prevalence of asymptomatic myocardial injury. We investigated whether influenza can produce myocardial injury without cardiac symptoms. METHODS: During the epidemic of influenza A (H3N2) from 1998 to 1999 in Japan, we examined possible cardiac muscle damage associated with influenza in patients without apparent clinical myocardial injury by measuring serum myosin light chain concentrations. PATIENTS: Ninety-six influenza-positive patients (46 males and 50 females, average age 43.4 years) without impaired renal function were studied. RESULTS: Of these patients, 11 (11.4%) had elevated serum myosin light chain I concentrations. CONCLUSION: Asymptomatic myocardial injury may be present in patients with influenza even when they have no symptoms suggestive of myocardial injury.
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Kaji et al. (2001) conducted an observational in Influenza A (H3N2) (n=96). Influenza A (H3N2) infection was evaluated on Elevated serum myosin light chain I (MLC I) concentrations. Among 96 patients with influenza A without cardiac symptoms, 11.4% had elevated serum myosin light chain I concentrations, suggesting the presence of asymptomatic myocardial injury.
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