Key result
Abnormal global longitudinal peak strain (GLPS) was identified as a sensitive marker for early myocardial disease in patients with hyperthyroidism, with 4% of the cohort exhibiting severe left ventricular systolic dysfunction.
Cross-Sectional (n=50)
No
Thyroid hormone alterations may reduce cardiac output in chronic states; hypothesis-generating and should not yet change practice.
The main function of Thyroid hormones is to maintain a balance in cardiac function along with the regulation of metabolism. A ny alterations in the thyroid hormone levels will further affect the normal functioning of the cardiac muscles. Initial raise in the hormones will result in increased contractility of the left ventricle resulting in the raise of cardiac output, whereas chronicity of the disease will cause reduction in normal behaviour of cardiac function, thereby causing increased risk of arrhythmias, reduction in global function of left ventricle, fibrosis and ultimately will result in heart failure. Cardiac dysfunction is one of the main causes of death in hyperthyroid cases, which is mainly due to remarkable changes in the haemodynamics resulting from abnormal muscle function of heart and diaphragm. Graves' disease was one of the commonest among the metabolic disorders to have its impact on cardiovascular system.
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U et al. (2018) conducted a cross-sectional in Hyperthyroidism (n=50). Hyperthyroidism was evaluated on Left ventricular systolic and diastolic dysfunction assessed by conventional and speckle tracking echocardiography. Abnormal global longitudinal peak strain (GLPS) was identified as a sensitive marker for early myocardial disease in patients with hyperthyroidism, with 4% of the cohort exhibiting severe left ventricular systolic dysfunction.
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