Key result
Intrarenal interstitial angiotensin II expression significantly correlated with glomerulosclerosis (r=0.86) and interstitial fibrosis (r=0.74) in dogs, while in cats it correlated with glomerulosclerosis (r=0.67) but not plasma creatinine.
Why the study?
Does the intrarenal renin-angiotensin system correlate with the severity of chronic kidney disease in dogs and cats?
Observational (n=36)
Does the intrarenal renin-angiotensin system correlate with the severity of chronic kidney disease in dogs and cats?
p-value: p=<0.01
The intrarenal renin-angiotensin system correlates with the severity of chronic kidney disease in dogs and cats, though the underlying mechanisms may differ between the species.
Supports species-specific intrarenal RAS roles in veterinary CKD; leaves open whether targeting it alters progression in dogs or cats.
The association of renin and angiotensin II, which are potent components of the renin-angiotensin system, with the severity of chronic renal disease was investigated immunohistochemically in dogs and cats. Immunoreactivities of renin and angiotensin II were evaluated quantitatively, and their correlations with the degrees of glomerulosclerosis, glomerular hypertrophy, interstitial cell infiltration and interstitial fibrosis were statistically analyzed. Immunoreactivities for renin were detected in afferent arteries in both dogs and cats. The score of renin-positive signals showed no correlation with plasma creatinine concentration or any of the histopathological parameters, except for the diameter of glomeruli in dogs. Immunoreactivities for angiotensin II were detected in tubules (primarily proximal tubules) and interstitial mononuclear cells in both dogs and cats. The score of tubular angiotensin II correlated with glomerulosclerosis and cell infiltration in cats but not in dogs. The score of interstitial angiotensin II correlated with plasma creatinine concentration, glomerulosclerosis, cell infiltration and fibrosis in dogs and with glomerulosclerosis and cell infiltration in cats. In conclusion, the results of the study suggest that intrarenal renin-angiotensin system is correlated with the severity of kidney disease, with the underlying mechanism differing between dogs and cats.
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Mitani et al. (2012) conducted an observational in Chronic kidney disease (n=36). Intrarenal renin and angiotensin II expression vs. Normal kidneys or lower expression levels was evaluated on Correlation between angiotensin II/renin immunoreactivity and histopathological parameters (glomerulosclerosis, cell infiltration, fibrosis) and plasma creatinine (p=<0.01). Intrarenal interstitial angiotensin II expression significantly correlated with glomerulosclerosis (r=0.86) and interstitial fibrosis (r=0.74) in dogs, while in cats it correlated with glomerulosclerosis (r=0.67) but not plasma creatinine.
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