Size, Hemoglobin Content, and Acid-Soluble Phosphorus of Erythrocytes of Rabbits with Phenylhydrazine-Induced Reticulocytosis

Following repeated injections of phenylhydrazine in rabbits, varying degrees of reticulocytosis, up to 100%, occur. With the increasing reticulocytosis the concentration of adenosine triphosphate in the erythrocytes increases from initial concentrations of 10 to 15 mg to 30 mg or more per 100 cc. The mean volume of the cells is greatly increased from around 60 n3 up to 150 ft3, and the corpuscular hemoglobin concentration is decreased from 34 to 22 g per 100 cc of cells.