Key result
Inhaled prostacyclin administration decreased pulmonary artery pressures from 70/37 to 45/23 mm Hg within 10 minutes in a patient with severe protamine-induced pulmonary hypertension.
Why the study?
Does inhaled prostacyclin reduce pulmonary artery pressures in a patient with severe protamine-induced pulmonary hypertension?
Case Report (n=1)
Does inhaled prostacyclin reduce pulmonary artery pressures in a patient with severe protamine-induced pulmonary hypertension?
Inhaled nebulized prostacyclin may be an effective selective pulmonary vasodilator for managing severe protamine-induced pulmonary hypertension without causing significant systemic hypotension.
May support inhaled prostacyclin for protamine-induced pulmonary hypertension; leaves open confirmation in prospective trials.
Acute pulmonary hypertension is a severe and life-threatening reaction that rarely occurs secondary to protamine administration. Management of systemic hypotension combined with severe pulmonary hypertension causing right ventricular failure is challenging. We describe a case of acute pulmonary hypertension induced by protamine during elective coronary artery bypass surgery refractory to multiple systemic inotropic and vasopressor therapies. After inhaled prostacyclin administration, our patient's pulmonary artery pressures decreased from 70/37 to 45/23 mm Hg within 10 min. The case highlights a role for inhaled nebulized prostacyclin as a selective pulmonary vasodilator with minimal systemic hypotensive effects.
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Jerath et al. (2010) conducted a case report in Acute pulmonary hypertension induced by protamine (n=1). Inhaled prostacyclin was evaluated on Pulmonary artery pressures. Inhaled prostacyclin administration decreased pulmonary artery pressures from 70/37 to 45/23 mm Hg within 10 minutes in a patient with severe protamine-induced pulmonary hypertension.
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