Key result
Protamine administration after cardiopulmonary bypass caused transient systemic hypotension (systolic pressure fell from 116 to 66 mmHg) and pulmonary hypertension (16.3 to 26.2 mmHg).
Why the study?
What are the systemic and pulmonary circulatory effects of protamine following cardiopulmonary bypass in men with normal left ventricular function?
Population
19 men with normal left ventricular function undergoing primary myocardial revascularization
Design
Case_series
Follow-up
Immediate post-infusion period (approx 2+ minutes)
Authors
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Warrants hemodynamic monitoring with protamine post-CPB even in normal LV function; leaves open broader applicability and causality.
Observational (n=19)
What are the systemic and pulmonary circulatory effects of protamine following cardiopulmonary bypass in men with normal left ventricular function?
Protamine administration after cardiopulmonary bypass causes transient systemic hypotension and pulmonary hypertension, which spontaneously reverse in patients with normal left ventricular function.
Øvrum et al. (1991) conducted an observational in Undergoing primary myocardial revascularization (n=19). Protamine was evaluated on Cardiovascular effects including arterial and pulmonary pressures. Protamine administration after cardiopulmonary bypass caused transient systemic hypotension (systolic pressure fell from 116 to 66 mmHg) and pulmonary hypertension (16.3 to 26.2 mmHg).
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