Key result
Intracoronary administration of protamine sulfate caused no significant change in left ventricular contractility, while intravenous administration produced hypotension due to peripheral vasodilation.
Why the study?
Does protamine sulfate cause myocardial depression or peripheral vasodilation in anesthetized dogs?
Does protamine sulfate cause myocardial depression or peripheral vasodilation in anesthetized dogs?
Protamine sulfate-induced hypotension is primarily due to peripheral vasodilation rather than direct myocardial depression.
Protamine hypotension in dogs is driven by vasodilation without myocardial depression; leaves open translation to human protamine use.
Rapid administration of protamine sulfate after arteriography or cardiopulmonary bypass has occasionally been associated with marked hypotension. Since it is unclear whether this is due entirely to vasodilatation or to myocardial depression in addition to vasodilatation, the authors assessed the direct myocardial and systemic circulatory effects of this drug in seven anesthetized dogs. Direct effects of protamine sulfate on global and regional myocardial function and peripheral arterial resistance were determined in the presence and absence of segmental myocardial ischemia. Effects on the myocardium were determined by intracoronary administration of protamine; effects on the systemic circulation were determined after intravenous administration. Intracoronary administration of protamine caused no significant change in left ventricular contractility in either the normal or ischemic state. Intravenous administration produced hypotension due to peripheral vasodilation.
No takes yet. Share an insight, caveat, or question.
Green et al. (1981) studied Anesthetized dogs (normal and ischemic state) (n=7). Protamine sulfate was evaluated on Global and regional myocardial function and peripheral arterial resistance. Intracoronary administration of protamine sulfate caused no significant change in left ventricular contractility, while intravenous administration produced hypotension due to peripheral vasodilation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: