Key result
Protamine sulfate produces cardiovascular depressant effects via a direct effect on the myocardium and vascular tree.
Why the study?
Does protamine sulfate cause cardiovascular depression through direct myocardial and vascular effects in anesthetized dogs?
Does protamine sulfate cause cardiovascular depression through direct myocardial and vascular effects in anesthetized dogs?
Protamine-induced hypotension and bradycardia are caused by direct depressant effects on the myocardium and vascular tree, rather than being mediated by autonomic reflexes or histamine release.
Authors
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Direct effects may underlie protamine hypotension clinically; leaves open translation from canine models to humans.
Fadali et al. (1974) studied Protamine-induced hypotension and bradycardia. Protamine sulfate vs. Control conditions was evaluated on Cardiovascular parameters including FAP, CVP, LVP, dp/dt, Vce, V max, and CO. Protamine sulfate produces cardiovascular depressant effects via a direct effect on the myocardium and vascular tree.
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