Why the study?
Does protamine sulfate cause cardiovascular depression in adult patients after cardiopulmonary bypass for CABG?
Population
15 adult patients who had undergone cardiopulmonary bypass for coronary artery bypass grafting
Design
Case_series
Follow-up
during or after administration
Authors
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Suggests protamine safety without hemodynamic effects post-CABG; hypothesis-generating, challenges canine models, needs prospective validation.
Does protamine sulfate cause cardiovascular depression in adult patients after cardiopulmonary bypass for CABG?
Protamine sulfate administered at typical clinical doses and rates does not cause significant cardiovascular depression in humans after cardiopulmonary bypass, contrary to previous findings in canine models.
Conahan et al. (1981) studied this question.
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