Protamine

Patients receiving protamine infusion to reverse heparin, including a subgroup with pulmonary artery hypertension (PAP > 25 mm Hg).

Protamine infusion (dose calculated as adequate to reverse heparin as measured by the activated clotting time).

Baseline measurements prior to protamine administration.

Alterations in right and left ventricular function (including right atrial pressure, right ventricular pressure, right ventricular ejection fraction, pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac output, blood pressure, and heart rate).surrogate