Why the study?
Is there an association between renin gene HindIII restriction fragment length polymorphism (RFLP) and a genetic predisposition to essential hypertension?
Is there an association between renin gene HindIII restriction fragment length polymorphism (RFLP) and a genetic predisposition to essential hypertension?
This study provides the first evidence of an association between renin gene restriction fragment length polymorphism and a genetic predisposition to essential hypertension in humans.
Renin gene 9.0-kb RFLP may mark hypertension predisposition; leaves open causal role and any clinical utility.
The genetic basis of essential hypertension is still uncertain. Because renin is thought to be a candidate gene for essential hypertension, a prospective study was conducted to compare the frequency of renin gene HindIII restriction fragment length polymorphism (RFLP) in normotensive and hypertensive subjects without (HTG-) and with a genetic predisposition to essential hypertension (HTG+). The frequency of the 9.0-kb fragment was significantly (p < 0.05) higher in the HTG+ group than in the normotensive and HTG- groups. An association between renin RFLP and hypertension in man was shown for the first time. It is suggested that a gene for blood pressure regulation has been localized to a part of the genome close to, or identical to, the renin locus.
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Morise et al. (2008) studied this question.
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