Key result
Combined diabetes mellitus and hypovitaminosis D significantly increased the risk of mortality, angina/MI, and heart failure in MI survivors (HR 1.69; 95% CI 1.25-2.29; p=0.001).
Why the study?
MI survivors, especially those with DM, remain at high risk of further events, prompting evaluation of how DM and hypovitaminosis D alone or combined affect prognosis.
Does the presence of diabetes mellitus and/or hypovitaminosis D worsen outcomes in patients surviving a myocardial infarction?
Observational (n=1,081)
Does the presence of diabetes mellitus and/or hypovitaminosis D worsen outcomes in patients surviving a myocardial infarction?
Hazard Ratio: 1.69 (95% CI 1.25–2.29)
p-value: p=0.001
Diabetes mellitus and vitamin D deficiency are independently and synergistically associated with worse clinical outcomes following a myocardial infarction.
No takes yet. Share an insight, caveat, or question.
Post-MI patients with DM plus hypovitD may face higher event risk; hypothesis-generating for targeted vitamin D trials.
Aleksova et al. (2020) conducted an observational in Myocardial infarction (n=1,081). Combined diabetes mellitus and hypovitaminosis D vs. Neither diabetes mellitus nor hypovitaminosis D was evaluated on Composite of all-cause mortality, angina/MI and heart failure (HF) (HR 1.69, 95% CI 1.25-2.29, p=0.001). Combined diabetes mellitus and hypovitaminosis D significantly increased the risk of mortality, angina/MI, and heart failure in MI survivors (HR 1.69; 95% CI 1.25-2.29; p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: