The synthesis of four new lignan derivatives 2a, 2b, 3a and 3b related to the anticancer agent etoposide has been accomplished. In these compounds a methylene or ethylene group of a C-glucoside separates the glucosidic moiety as present in etoposide (1) from its lignan aglycone bonded by an ethereal function. The key step in the synthesis involves the reaction of a benzylated alditol 4 or 5 and the unprotected 4′-demethylepipodophyllotoxin (6).
No takes yet. Share an insight, caveat, or question.
Allevi et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: