Why the study?
Does obesity increase the sensitivity to mineralocorticoid-induced hypertension in a Zucker rat model?
Population
Unilaterally nephrectomized lean and obese Zucker rats
Comparison
Deoxycorticosterone acetate 25 mg/kg injected… vs Unilaterally nephrectomized control rats…
Design
Preclinical
Follow-up
5 weeks
Authors
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Supports obesity as a modifier of mineralocorticoid hypertension sensitivity in rats; leaves open translation to human mechanisms and management.
Does obesity increase the sensitivity to mineralocorticoid-induced hypertension in a Zucker rat model?
Obese Zucker rats are more sensitive to mineralocorticoid-induced hypertension and renal damage than lean rats, providing experimental support for the epidemiological link between obesity and hypertension.
Morrison et al. (2002) studied this question.
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