Population
Lower and higher order mammalian models (renal pelvic smooth muscle)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for HCN-targeted therapies in urinary tract disorders; prospective human studies required before clinical adoption.
HCN channels play an evolutionarily conserved pacemaker role in renal pelvic smooth muscle, driving pacemaker activity and peristaltic contractions.
Coupland et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: